pentobarbital decreases results of sufentanil SL by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Closely. Coadministration of CYP3A4 inducers might lessen sufentanil stages and efficacy, probably precipitating withdrawal syndrome in clients who have produced physical dependence to sufentanil. Discontinuation of concomitantly applied CYP3A4 inducers may increase sufentanil plasma concentration.
Observe Carefully (one)pentobarbital will minimize the level or influence of benzhydrocodone/acetaminophen by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Closely. Warning when discontinuing CYP3A4 inducers which are coadministered with benzhydrocodone (prodrug of hydrocodone); plasma concentrations of hydrocodone may well improve and may result in possibly lethal respiratory despair.
pentobarbital will minimize the extent or impact of quetiapine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
Warning is warranted for people with renal and hepatic impairment. Although the producer won't present precise dosage adjustment suggestions for renal impairment, checking kidney operate when administering significant doses or conducting extended cure is very important.
pentobarbital will reduce the level or effect of voriconazole by influencing hepatic enzyme CYP2C9/ten metabolism. Small/Significance Unfamiliar.
pentobarbital will lessen the extent or result of ziprasidone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unfamiliar.
Monitor Closely (one)pentobarbital will decrease the level or effect of mifepristone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. CYP3A4 inducers have not been researched, coadministration not advisable by manufacturer
pentobarbital will lower the level or impact of etravirine by affecting hepatic enzyme CYP2C9/10 read more metabolism. Use Caution/Observe.
pentobarbital will reduce the extent or impact of triamcinolone acetonide injectable suspension by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
pentobarbital will reduce the extent or impact of iloperidone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
benzhydrocodone/acetaminophen and pentobarbital each improve sedation. Steer clear of or Use Alternate Drug. Limit use to individuals for whom option treatment options are insufficient
pentobarbital will reduce the extent or result of ramelteon by affecting hepatic enzyme CYP2C9/ten metabolism. Small/Significance Not known.
Check Intently (one)pentobarbital will lower the extent or effect of gefitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will lower the level or impact of irinotecan by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.